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Gianotti–Crosti syndrome
Gianotti–Crosti syndrome (also known as "Infantile papular acrodermatitis,"〔 "Papular acrodermatitis of childhood," and "Papulovesicular acrolocated syndrome") is a reaction of the skin to a viral infection.〔(【引用サイトリンク】title=Gianotti-crosti syndrome, papulovesicular acrodermatitis. DermNet NZ )〕 Hepatitis B and Epstein-Barr virus are the most frequently reported etiologies. Other incriminated viruses are hepatitis A, hepatitis non A-non B, strep, cytomegalovirus, coxsackie, adenovirus, enterovirus, rotavirus, rubella, HIV and parainfluenza.
It is named for Ferdinando Gianotti and Agostino Crosti.
==Clinical features==
Gianotti–Crosti syndrome mainly affects infants and young children. Children of age as low as 1.5 months and up to 12 years of age are reported to be affected. It is generally recognized as a papular or papulovesicular skin rash occurring mainly on the face and distal aspects of the four limbs. Purpura is generally not seen but may develop following application of tourniquet. However extensive purpura without any hemorrhagic disorder has been reported.〔 The presence of less florid truncal lesions does not exclude the diagnosis. Lymphadenopathy and hepatomegaly are sometimes noted. Raised liver transaminases with no rise in conjugated and unconjugated bilirubin are sometimes detectable, although the absence of such does not exclude the diagnosis. Spontaneous disappearance of the rash usually occurs after 15–60 days.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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